Contract notice
Section I: Contracting
authority
I.1) Name and addresses
UNIVERSITY OF MANCHESTER
10007798
John Owens Building, Oxford Road
MANCHESTER
M13 9PL
UK
Contact person: Paul Carter
E-mail: paul.carter-2@manchester.ac.uk
NUTS: UKD33
Internet address(es)
Main address: http://www.procurement.manchester.ac.uk/
I.3) Communication
The procurement documents are available for unrestricted and full direct access, free of charge at:
https://in-tendhost.co.uk/manchesteruniversity/aspx/Tenders/Current
Additional information can be obtained from the abovementioned address
Tenders or requests to participate must be sent electronically to:
https://in-tendhost.co.uk/manchesteruniversity/aspx/Tenders/Current
I.4) Type of the contracting authority
Body governed by public law
I.5) Main activity
Education
Section II: Object
II.1) Scope of the procurement
II.1.1) Title
Integrated bioreactor platform for rapid scale-up and translation
Reference number: 2023-2033-BRS-JW-PC
II.1.2) Main CPV code
42993000
II.1.3) Type of contract
Supplies
II.1.4) Short description
This tender is being run on behalf of Dr James Winterburn, Reader in Chemical Engineering. Dr Winterburn led a successful BBSRC ALERT21 equipment bid "Integrated bioreactor platform for rapid scale-up and translation", which will provide significant bioreactor capacity for microbial fermentation process development, scale up and translation for a range of bio-based chemicals. The exploitation of bio-based production routes requires a thorough understanding of production strain performance and an ability to rapidly and effectively scale processes from millilitres to tens of litres. The bioreactor platform is intended to provide understanding of how process conditions at different volumes and variability across process parameters (e.g., mixing speeds, dissolved O2, pH), affect host cell performance. The integrated bioreactor platform will bridge across three scales, outlined below, and allow for rapid process development and ultimately support research translation.
Small-scale: Parallel bioreactor system (500 mL, 6 vessels) for rapid parallel process development, strain testing and parameter optimization for microbial fermentations in batch, fed-batch and continuous cultivation, with off gas analysis capability
Mid-scale (3L bioreactor system, four vessels): For initial scale up and process development work (e.g., confirmation of feeding profiles, metabolic profiling) and preliminary process analysis (including; yield, productivity, final titre) with off gas analysis capability. Also serves as the seed train for inoculum preparation for scale up to 40L.
Large-scale feasibility (40L SIP bioreactor): To enable in-house demonstration of process technical feasibility, production of sufficient quantities of material for application testing and benchmarking and provision of data for robust techno-economic analysis which can be used as the basis for commercialisation, also with off gas analysis capability.
II.1.6) Information about lots
This contract is divided into lots:
No
II.2) Description
II.2.2) Additional CPV code(s)
38000000
II.2.3) Place of performance
NUTS code:
UKD3
Main site or place of performance:
The University of Manchester
II.2.4) Description of the procurement
This tender is being run on behalf of Dr James Winterburn, Reader in Chemical Engineering. Dr Winterburn led a successful BBSRC ALERT21 equipment bid "Integrated bioreactor platform for rapid scale-up and translation", which will provide significant bioreactor capacity for microbial fermentation process development, scale up and translation for a range of bio-based chemicals. The exploitation of bio-based production routes requires a thorough understanding of production strain performance and an ability to rapidly and effectively scale processes from millilitres to tens of litres. The bioreactor platform is intended to provide understanding of how process conditions at different volumes and variability across process parameters (e.g., mixing speeds, dissolved O2, pH), affect host cell performance. The integrated bioreactor platform will bridge across three scales, outlined below, and allow for rapid process development and ultimately support research translation.
Small-scale: Parallel bioreactor system (500 mL, 6 vessels) for rapid parallel process development, strain testing and parameter optimization for microbial fermentations in batch, fed-batch and continuous cultivation, with off gas analysis capability
Mid-scale (3L bioreactor system, four vessels): For initial scale up and process development work (e.g., confirmation of feeding profiles, metabolic profiling) and preliminary process analysis (including; yield, productivity, final titre) with off gas analysis capability. Also serves as the seed train for inoculum preparation for scale up to 40L.
Large-scale feasibility (40L SIP bioreactor): To enable in-house demonstration of process technical feasibility, production of sufficient quantities of material for application testing and benchmarking and provision of data for robust techno-economic analysis which can be used as the basis for commercialisation, also with off gas analysis capability.
II.2.5) Award criteria
Price is not the only award criterion and all criteria are stated only in the procurement documents
II.2.7) Duration of the contract, framework agreement or dynamic purchasing system
Start:
08/06/2023
End:
14/02/2024
This contract is subject to renewal: No
II.2.9) Information about the limits on the number of candidates to be invited
II.2.10) Information about variants
Variants will be accepted:
No
II.2.11) Information about options
Options:
No
II.2.13) Information about European Union funds
The procurement is related to a project and/or programme financed by European Union funds:
No
Section IV: Procedure
IV.1) Description
IV.1.1) Type of procedure
Open procedure
IV.1.8) Information about Government Procurement Agreement (GPA)
The procurement is covered by the Government Procurement Agreement:
Yes
IV.2) Administrative information
IV.2.2) Time limit for receipt of tenders or requests to participate
Date:
25/05/2023
Local time: 12:00
IV.2.4) Languages in which tenders or requests to participate may be submitted
EN
IV.2.6) Minimum time frame during which the tenderer must maintain the tender
Duration in months: 3 (from the date stated for receipt of tender)
IV.2.7) Conditions for opening of tenders
Date:
25/05/2023
Local time: 12:05
Place:
The University of Manchester
Information about authorised persons and opening procedure:
The University of Manchester staff only
Section VI: Complementary information
VI.1) Information about recurrence
This is a recurrent procurement:
No
VI.2) Information about electronic workflows
Electronic ordering will be used
Electronic invoicing will be accepted
Electronic payment will be used
VI.4) Procedures for review
VI.4.1) Review body
The University of Manchester
Manchester
UK
VI.5) Date of dispatch of this notice
24/04/2023