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Summary

OCID:: ocds-kuma6s-114050
Published by:: Cardiff University
Authority ID:: AA0258
Publication date:: 15 September 2021
Deadline date:: -
Notice type:: 15 Voluntary ex ante Transparency (VEAT) Notice
Has documents:: No
Has SPD:: No
Has Carbon Reduction Plan:: N/A

Abstract

NanoString GeoMX and nCounter instruments CPV: 38432000, 38432000.

Full notice text

Voluntary ex ante transparency notice

Directive 2014/24/EU

Section I: Contracting entity

I.1) Name and addresses

Cardiff University

Procurement Services, McKenzie House, 30-36 Newport Road

Cardiff

CF24 0DE

Telephone: +44 2920879648

E-mail: procurement@cardiff.ac.uk

NUTS: UKL

Internet address(es)

Main address: http://www.cardiff.ac.uk/business/why-work-with-us/for-suppliers

Address of the buyer profile: https://www.sell2wales.gov.wales/search/Search_AuthProfile.aspx?ID=AA0258

I.4) Type of the contracting authority

Body governed by public law

I.5) Main activity

Education

Section II: Object

II.1) Scope of the procurement

II.1.1) Title

GeoMx Digital Spatial Profiler and nCounter

Reference number: CU.732.TH

II.1.2) Main CPV code

38432000

II.1.3) Type of contract

Supplies

II.1.4) Short description

NanoString GeoMX and nCounter instruments

II.1.6) Information about lots

This contract is divided into lots: No

II.1.7) Total value of the procurement

Value excluding VAT: 300 000.00 GBP

II.2) Description

II.2.2) Additional CPV code(s)

38432000

II.2.3) Place of performance

NUTS code:

UKL22

II.2.4) Description of the procurement

The GeoMx DSP is a novel digital technology (proprietary

to NanoString) that is based on multiplexed measurement

of protein and nucleic acids and offers unparalleled levels of

precision coupled with the ability to quantify up to 96 proteins

and over 1000 RNA targets on a formalin-fixed, paraffinembedded

(FFPE) tissue section on a microscope slide.

II.2.11) Information about options

Options: No

II.2.13) Information about European Union funds

The procurement is related to a project and/or programme financed by European Union funds: No

Section IV: Procedure

IV.1) Description

IV.1.1) Type of procedure

Award of a contract without prior publication of a call for competition

Justification for selected award procedure:

The procurement falls outside the scope of application of the Directive

Explanation:

The GeoMx Digital Spatial Profiler (DSP)

is only available from NanoString

Technologies, Inc.

The GeoMx DSP is a novel digital technology (proprietary

to NanoString) that is based on multiplexed measurement

of protein and nucleic acids and offers unparalleled levels of

precision coupled with the ability to quantify up to 96 proteins

and over 1000 RNA targets on a formalin-fixed, paraffinembedded

(FFPE) tissue section on a microscope slide.

In contrast to the sequential analysis of multi-target

immunohistochemistry (IHC) slides, the GeoMx DSP samples

all protein or RNA analytes on a single slide. This not only

shortens experiments and simplifies data analysis, but also

provides a higher multiplexing capacity (96 targets) all with

spatial context from Formalin-Fixed, Paraffin-Embedded

(FFPE) tissue sections.

Based on NanoString’s proprietary digital barcoding

technology, the GeoMx DSP platform measures local protein

levels, and can be combined with RNA expression, within

heterogeneous tissue samples. Combining both multiplexed

nucleic acid and protein on the same platform gives

researchers the ability to spatially resolve RNA when suitable

antibodies do not exist. The GeoMx DSP assay is performed on

the GeoMx DSP platform which includes imaging and fluidic

components to capture spatial context, and current nCounter®

or next-generation sequencing (NGS) instruments provide the

quantification.

Protein detection is enabled via primary antibodies which

are covalently attached via a UV photocleavable linker to

DNA indexing oligos. Following antigen retrieval, FFPE tissue

samples are stained with a multiplexed cocktail of labeled

antibodies, and DNA oligos are subsequently released by

UV light exposure across regions of interest. The liberated

DNA oligos are then hybridized to optical barcodes for

quantitation on an nCounter or NGS instrument. This

technique enables quantitative, multiplexed protein detection

up to 5.5 logs of dynamic range.

Key Features and Benefits of DSP technology

- Multiplex many analytes on one tissue section in

a single pass

- Quantitation based on linear single-molecule

counting: up to 5.5 logs

- Single-cell limit of detection

- Non-destructive: sample completely intact after assay

- Single antigen retrieval without effects from

order-of-addition

IV.1.8) Information about Government Procurement Agreement (GPA)

The procurement is covered by the Government Procurement Agreement: Yes

Section V: Award of contract/concession

Contract No: CU.732.TH

V.2 Award of contract/concession

V.2.1) Date of conclusion of the contract/concession

15/09/2021

V.2.2) Information about tenders

The contract has been awarded to a group of economic operators: No

V.2.3) Name and address of the contractor

NanoString Technologies

St. Marys Court, The Broadway

Amersham

HP70UT

Telephone: +44 7468604366

NUTS: UK

The contractor is an SME: Yes

V.2.4) Information on value of the concession and main financing terms (excluding VAT)

Total value of the concession/lot: 300 000.00 GBP

V.2.5) Information about subcontracting

Section VI: Complementary information

VI.3) Additional information

(WA Ref:114050)

VI.4) Procedures for review

VI.4.1) Review body

High Court

Royal Courts of Justice, The Strand

London

WC2A 2LL

Telephone: +44 2079477501

VI.5) Date of dispatch of this notice